Efficacy of a Proteome-Targeting Serum on Aging Signs Across Multiple Ethnicities and Phototypes: A Multicenter, Real-World Dermatology Study

The proteome is the set of proteins of a cell or tissue. Proteome impairement is the root cause of skin aging: with age, carbonylation irreversibly alters proteins’ conformation resulting in loss of their functionalities and premature aging signs. Protecting its integrity can slow down the aging process. Because proteins are the main component of the body after water, their preservation is key for cellular and skin longevity.
A serum containing a chaperone-like antioxidant patented active ingredient protecting the proteome, demonstrated, in a six-months split face comparative monocentric clinical study (55 caucasian French women), a preventive and long lasting corrective efficacy on aging signs.
Wrinkles (crow’s feet, underneath eye area, nasolabial fold), skin radiance, homogeneity (pigmented spot appearance and complexion homogeneity), firmness and density were explored on each half face: one treated with neutral cream, the other treated with both the neutral cream and the Proteome-targeting serum. From 8 weeks, all graded signs were significantly better improved on the side treated with serum. A cumulative effect was observed over 2 to 6 months without reaching a plateau.
A two-month, multicenter open study was launched to evaluate the efficacy and tolerance of the serum in a larger, more diverse multi-ethnic group of participants. The study aimed to assess both short- and long-term dermatologically graded effects (from two weeks to two months) of the serum under real-world conditions in dermatologists’ private practices.